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Article

249(ser) TP53 mutation in plasma DNA, hepatitis B viral infection, and risk of hepatocellular carcinoma.

Oncogene - 1 Sept 2005

Kirk Gregory D, Lesi Olufunmilayo A, Mendy Maimuna, Szymañska Katarzyna, Whittle Hilton, Goedert James J, Hainaut Pierre, Montesano Ruggero

Abstract excerpt

Hepatocellular carcinoma (HCC) from regions with high dietary exposure to aflatoxins and endemic for hepatitis B virus (HBV) often contain a specific mutation at codon 249 in TP53 (249(ser); AGG to AGT, Arg to Ser). This mutation is also detectable in circulating cell-free DNA from the plasma of HCC patients and healthy subjects in these regions. We have examined the joint effect of plasma 249(ser) and HBV...

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Share to Aflatoxins
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, p53

Share to Hepatitis B

Share to Hepatitis B virus

Share to Liver Neoplasms

Share to Polymorphism, Restriction Fragment Length

Source

Identifiers

PMID: 16007211
DOI: 10.1038/sj.onc.1208732

Genes

TP53
AGT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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