Article
P53 mutations in hepatocellular carcinoma patients in Egypt.
International journal of hygiene and environmental health - 1 Jan 2005
El-Kafrawy Sherif A, Abdel-Hamid Mohamed, El-Daly Mai, Nada Ola, Ismail Alaa, Ezzat Sameera, Abdel-Latif Soheir, Abdel-Hamid Amany, Shields Peter G, Loffredo Christopher
Abstract excerpt
The p53 gene plays a major role in hepatocellular carcinoma (HCC). Acquired mutations may provide clues to etiology, as some carcinogenic agents are associated with specific genetic changes in p53. Our aim was to analyze the spectrum of p53 mutations in tumor tissues from subjects with HCC in Egypt, where there is a rising incidence of HCC due to hepatitis C virus (HCV). We collected tumor tissues from 41...
Topics
- Adult
- Aged
- Carcinoma, Hepatocellular
- DNA Mutational Analysis
- Egypt
- Exons
- Female
- Genes, p53
- Hepacivirus
- Hepatitis C
- Humans