Article
The prevalence of the mutation in codon 249 of the P53 gene in patients with hepatocellular carcinoma (HCC) in Turkey.
Journal of gastrointestinal cancer - 1 Sept 2010
Ozdemir Filiz Türe, Tiftikci Arzu, Sancak Seda, Eren Fatih, Tahan Veysel, Akın Hakan, Gündüz Feyza, Kedrah Ala Eldeen, Ustündağ Yücel, Avşar Erol, Tözün Nurdan, Ozdoğan Osman
Abstract excerpt
UNLABELLED: Hepatocellular carcinoma (HCC) is one of the most common cancers in the worldwide. Aflotoxins, products of Aspergillus Flavus found in the high humidity environments induce HCC in humans by causing mutations in oncogenes such as codon 249 mutation of p53 in hepatocytes. In turkey, aflatoxins are found to be increased in some foods in certain areas, such as Istanbul which have high humidity. In present...
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