High prevalence of mutations at codon 249 of the p53 gene in hepatocellular carcinomas from Senegal.

doi:10.1038/bjc.1993.258

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Article

High prevalence of mutations at codon 249 of the p53 gene in hepatocellular carcinomas from Senegal.

British journal of cancer - 1 Jun 1993

Coursaget P, Depril N, Chabaud M, Nandi R, Mayelo V, LeCann P, Yvonnet B

Abstract excerpt

In hepatocellular carcinoma, mutation within the p53 gene occurs mainly at codon 249 and its frequency has been associated with exposure to aflatoxin. As Senegal is a country where liver cancer incidence is one of the highest in the world and where people are highly exposed to aflatoxin, we scree...

Topics

Base Sequence
Carcinoma, Hepatocellular
Codon
DNA, Neoplasm
DNA, Viral
Genes, p53
Hepatitis B
Hepatitis B virus
Humans
Liver Neoplasms
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Prevalence
Senegal

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