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Article

High prevalence of mutations at codon 249 of the p53 gene in hepatocellular carcinomas from Senegal.

British journal of cancer - 1 Jun 1993

Coursaget P, Depril N, Chabaud M, Nandi R, Mayelo V, LeCann P, Yvonnet B

Abstract excerpt

In hepatocellular carcinoma, mutation within the p53 gene occurs mainly at codon 249 and its frequency has been associated with exposure to aflatoxin. As Senegal is a country where liver cancer incidence is one of the highest in the world and where people are highly exposed to aflatoxin, we screened 15 liver cancer samples from this country for mutation at codon 249 of the p53 gene. Non-tumoral DNA from the...

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Identifiers

PMID: 8390289
DOI: 10.1038/bjc.1993.258
PMCID: PMC1968506

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Source receipt: pubmed, retrieved 7 Sept 2026.

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