Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Secretin receptor oligomers form intracellularly during maturation through receptor core domains.

Biochemistry - 11 Jul 2006

Lisenbee Cayle S, Miller Laurence J

Abstract excerpt

Oligomerization of numerous G protein-coupled receptors has been documented, including the prototypic family B secretin receptor. The clinical significance of oligomerization of this receptor became clear with the recent observation that a misspliced form present in pancreatic cancer could associate with the wild-type receptor and act as a dominant negative inhibitor of its normal growth inhibitory function. Our...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alanine
Share to Amino Acid Motifs
Share to Cell Membrane

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorescence Resonance Energy Transfer

Share to Luminescent Proteins

Share to Organelles

Share to Protein Transport

Share to Receptors, G-Protein-Coupled

Source

Open in PubMed Open full text

Identifiers

PMID: 16819820
DOI: 10.1021/bi060494y
PMCID: PMC2505178

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Secretin receptor oligomers form intracellularly during maturation through receptor core domains.PMID 16819820Read ↗

Impact of secretin receptor homo-dimerization on natural ligand binding.Semantic proximity Read ↗

Functional segregation of the highly conserved basic motifs within the third endoloop of the human secretin receptor.Semantic proximity Read ↗

Importance of lipid-exposed residues in transmembrane segment four for family B calcitonin receptor homo-dimerization.Semantic proximity Read ↗

Signaling Modification by GPCR Heteromer and Its Implication on X-Linked Nephrogenic Diabetes Insipidus.Semantic proximity Read ↗

A critical role for the short intracellular C terminus in receptor activity-modifying protein function.Semantic proximity Read ↗

Oligomerization of wild type and nonfunctional mutant angiotensin II type I receptors inhibits galphaq protein signaling but not ERK activation.Semantic proximity Read ↗

Secretin receptor as a target in gastrointestinal cancer: expression analysis and ligand developmentSemantic proximity Read ↗

The effects of C-terminal truncation of receptor activity modifying proteins on the induction of amylin receptor phenotype from human CTb receptors.Semantic proximity Read ↗

Differential determinants for coupling of distinct G proteins with the class B secretin receptor.Semantic proximity Read ↗

Structure and Function of Cross-class Complexes of G Protein-coupled Secretin and Angiotensin 1a Receptors.Semantic proximity Read ↗

The melanocortin 4 receptor: oligomer formation, interaction sites and functional significance.Semantic proximity Read ↗

Cell surface delivery and structural re-organization by pharmacological chaperones of an oligomerization-defective alpha(1b)-adrenoceptor mutant demonstrates membrane targeting of GPCR oligomers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.