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Article

The melanocortin 4 receptor: oligomer formation, interaction sites and functional significance.

Biochimica et biophysica acta - 1 Feb 2013

Chapman Kathryn L, Findlay John B C

Abstract excerpt

This study involves the structural and functional properties of the recombinant melanocortin 4 receptor (MC(4)R) expressed in the HEK-293 cell line. Using co-immuno-purification approaches, the receptor appears to be an oligomer, which can be crosslinked through disulphide bonds involving a native cysteine residue (84) to give a dimeric species. This position is located near the cytosolic region of transmembrane...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23088915
DOI: 10.1016/j.bbamem.2012.10.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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