Article
Importance of lipid-exposed residues in transmembrane segment four for family B calcitonin receptor homo-dimerization.
Regulatory peptides - 24 Sept 2010
Harikumar Kaleeckal G, Ball Alicja M, Sexton Patrick M, Miller Laurence J
Abstract excerpt
Dimerization of the prototypic family B G protein-coupled secretin receptor is determined by the lipid-exposed face of transmembrane segment four (TM4), and has substantial functional importance, facilitating G protein coupling. Recently, we demonstrated that the human secretin receptor elicits an inter-receptor bioluminescence resonance energy transfer (BRET) signal with most other human family B peptide...
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