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Article

Functional segregation of the highly conserved basic motifs within the third endoloop of the human secretin receptor.

Endocrinology - 1 Sept 2001

Chan K Y, Pang R T, Chow B K

Abstract excerpt

In this study, a mutagenesis-based strategy was employed to assess the roles of two highly conserved motifs (KLR and RLAR) within the third endoloop of the human secretin receptor. Block deletion of KLRT and mutation of Lys323 (K(323)I) significantly reduced cAMP accumulation, and these mutations did not affect ligand interaction and receptor number expressed on the cell surface. Thus, the KLRT region at the N...

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Identifiers

PMID: 11517171
DOI: 10.1210/endo.142.9.8389

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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