Article

Secretin receptor as a target in gastrointestinal cancer: expression analysis and ligand development

2022-02-01

Abstract excerpt

Secretin was originally discovered as a gastrointestinal peptide that stimulates fluid secretion from pancreas and liver and delays gastric emptying. In disease, secretin receptor (SCTR) was found to occur as a splice variant in gastrinoma and pancreatic adenocarcinoma. Overexpression of SCTR has been described for gastrinomas, carcinoid tumors of the lung and cholangiocarcinoma. SCTR therefore remains a candidate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 24837685-8232-53fb-a3d5-eb8e83a17693
DOI: 10.1101/2022.01.31.478443

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Secretin receptor as a target in gastrointestinal cancer: expression analysis and ligand developmentDOI 10.1101/2022.01.31.478443Read

Functional segregation of the highly conserved basic motifs within the third endoloop of the human secretin receptor.Semantic proximity Read

G protein-coupled receptors as promising cancer targets.Semantic proximity Read

Targeting gastrin releasing peptide receptors: New options for the therapy and diagnosis of cancerSemantic proximity Read

Impact of secretin receptor homo-dimerization on natural ligand binding.Semantic proximity Read

Somatostatin Receptor Based Imaging and Radionuclide TherapySemantic proximity Read

Secretin receptor oligomers form intracellularly during maturation through receptor core domains.Semantic proximity Read

Mapping spatial approximations between the amino terminus of secretin and each of the extracellular loops of its receptor using cysteine trapping.Semantic proximity Read

New Developments in Peptide Receptor Radionuclide TherapySemantic proximity Read

The effects of C-terminal truncation of receptor activity modifying proteins on the induction of amylin receptor phenotype from human CTb receptors.Semantic proximity Read

Spatial approximation between two residues in the mid-region of secretin and the amino terminus of its receptor. Incorporation of seven sets of such constraints into a three-dimensional model of the agonist-bound secretin receptor.Semantic proximity Read

Development of the novel amylin receptor activators with nanomolar potency by peptide mutagenesisSemantic proximity Read

Signaling Modification by GPCR Heteromer and Its Implication on X-Linked Nephrogenic Diabetes Insipidus.Semantic proximity Read