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Article

Differential determinants for coupling of distinct G proteins with the class B secretin receptor.

American journal of physiology. Cell physiology - 15 Apr 2012

Garcia Gene L, Dong Maoqing, Miller Laurence J

Abstract excerpt

The secretin receptor is a prototypic class B G protein-coupled receptor that is activated by binding of its natural peptide ligand. The signaling effects of this receptor are mediated by coupling with Gs, which activates cAMP production, and Gq, which activates intracellular calcium mobilization. We have explored the molecular basis for the coupling of each of these G proteins to this receptor using systematic...

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Identifiers

PMID: 22277758
DOI: 10.1152/ajpcell.00273.2011
PMCID: PMC3330731

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