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Article

Impact of secretin receptor homo-dimerization on natural ligand binding.

Nature communications - 23 May 2024

Harikumar Kaleeckal G, Piper Sarah J, Christopoulos Arthur, Wootten Denise, Sexton Patrick M, Miller Laurence J

Abstract excerpt

Class B G protein-coupled receptors can form dimeric complexes important for high potency biological effects. Here, we apply pharmacological, biochemical, and biophysical techniques to cells and membranes expressing the prototypic secretin receptor (SecR) to gain insights into secretin binding to homo-dimeric and monomeric SecR. Spatial proximity between peptide and receptor residues, probed by disulfide bond...

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Identifiers

PMID: 38782989
DOI: 10.1038/s41467-024-48853-6
PMCID: PMC11116414

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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