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Article

Signaling Modification by GPCR Heteromer and Its Implication on X-Linked Nephrogenic Diabetes Insipidus.

PloS one - 1 Jan 2016

Ng Hans K H, Harikumar Kaleeckal G, Miller Laurence J, Chow Billy K C

Abstract excerpt

The involvement of secretin (SCT) and secretin receptor (SCTR) in regulating body water homeostasis is well established. Identified as one of the vasopressin (Vp)-independent mechanisms in fluid balance, SCT regulates aquaporin 2 (AQP2) in the kidney distal collecting duct cells through activating intracellular cAMP production. This ability to bypass Vp-mediated water reabsorption in kidney implicates SCT's...

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Share to Diabetes Insipidus, Nephrogenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Diseases, X-Linked

Share to Microscopy, Confocal

Share to Protein Multimerization

Share to Receptors, G-Protein-Coupled

Share to Receptors, Vasopressin

Source

Open in PubMed Open full text

Identifiers

PMID: 27649563
DOI: 10.1371/journal.pone.0163086
PMCID: PMC5029868

Genes

AVPR2
SCTR
SCT
AQP2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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