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Article

Subtle variations in Pten dose determine cancer susceptibility.

Nature genetics - 1 May 2010

Alimonti Andrea, Carracedo Arkaitz, Clohessy John G, Trotman Lloyd C, Nardella Caterina, Egia Ainara, Salmena Leonardo, Sampieri Katia, Haveman William J, Brogi Edi, Richardson Andrea L, Zhang Jiangwen, Pandolfi Pier Paolo

Abstract excerpt

Cancer susceptibility has been attributed to at least one heterozygous genetic alteration in a tumor suppressor gene (TSG). It has been hypothesized that subtle variations in TSG expression can promote cancer development. However, this hypothesis has not yet been definitively supported in vivo. Pten is a TSG frequently lost in human cancer and mutated in inherited cancer-predisposition syndromes. Here we analyze...

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Identifiers

PMID: 20400965
DOI: 10.1038/ng.556
PMCID: PMC3118559

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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