Article
Allele-specific tumor spectrum in pten knockin mice.
Proceedings of the National Academy of Sciences of the United States of America - 16 Mar 2010
Wang Hui, Karikomi Matt, Naidu Shan, Rajmohan Ravi, Caserta Enrico, Chen Hui-Zi, Rawahneh Maysoon, Moffitt Julie, Stephens Julie A, Fernandez Soledad A, Weinstein Michael, Wang Danxin, Sadee Wolfgang, La Perle Krista, Stromberg Paul, Rosol Thomas J, Eng Charis, Ostrowski Michael C, Leone Gustavo
Abstract excerpt
Germline mutations in the tumor suppressor gene PTEN (phosphatase and tensin homology deleted on chromosome 10) cause Cowden and Bannayan-Riley-Ruvalcaba (BRR) syndromes, two dominantly inherited disorders characterized by mental retardation, multiple hamartomas, and variable cancer risk. Here, we modeled three sentinel mutant alleles of PTEN identified in patients with Cowden syndrome and show that the nonsense...
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