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Article

Haploinsufficiency of the <i>Pten</i> tumor suppressor gene promotes prostate cancer progression

11 Sept 2001

Abstract excerpt

The PTEN gene encodes a lipid phosphatase that negatively regulates the phosphatidylinositol 3-kinase pathway and is inactivated in a wide variety of malignant neoplasms. High rates of loss of heterozygosity are observed at the 10q23.3 region containing the human PTEN gene in prostate cancer and other human malignancies, but the demonstrated rate of biallelic inactivation of the PTEN gene by mutation or...

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PMID: 11553783
DOI: 10.1073/pnas.201167798

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Related research

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Research trail→

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Haploinsufficiency of the <i>Pten</i> tumor suppressor gene promotes prostate cancer progressionPMID 11553783Read ↗

The <i>PTEN</i> gene in locally progressive prostate cancer is preferentially inactivated by bi‐allelic gene deletionSemantic proximity Read ↗

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The biology and clinical relevance of the PTEN tumor suppressor pathway.Semantic proximity Read ↗

<i>Pten</i> deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiationSemantic proximity Read ↗

<i>PTEN</i> genomic deletions that characterize aggressive prostate cancer originate close to segmental duplicationsSemantic proximity Read ↗

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