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Article

The gene dosage of class Ia PI3K dictates the development of PTEN hamartoma tumor syndrome.

Cell cycle (Georgetown, Tex.) - 1 Dec 2013

Wang Qi, Weisberg Ellen, Zhao Jean J

Abstract excerpt

The PTEN hamartoma tumor syndrome (PHTS) is a complex disorder caused by germline inactivating mutations of the tumor suppressor gene PTEN. Loss of PTEN function leads to unimpeded phosphatidylinositol-3'-kinase (PI3K) activity and PI3K-driven cell division. Individuals with PHTS develop benign h...

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Source

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Identifiers

PMID: 24131925
DOI: 10.4161/cc.26812
PMCID: PMC3903710

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24131925-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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The gene dosage of class Ia PI3K dictates the development of PTEN hamartoma tumor syndrome.PMID 24131925Read ↗

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