Article
Overexpression of glutathione S-transferase and elevation of thiol pools in a multidrug-resistant human colon cancer cell line.
Molecular pharmacology - 1 Jan 1992
Chao C C, Huang Y T, Ma C M, Chou W Y, Lin-Chao S
Abstract excerpt
A human colon cancer cell line with acquired multidrug resistance (MDR) was assayed for the intracellular GSH level and the activity of GSH-S-transferase (GST), which catalyzes the conjugation reaction of electrophilic drugs with GSH. The GSH level and GST activity (as measured with 1-chloro-2,4-...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Antimetabolites, Antineoplastic
- Buthionine Sulfoximine
- Colonic Neoplasms
- Doxorubicin
- Drug Resistance
- Gene Expression
- Glutathione
- Glutathione Transferase
- HeLa Cells
- Humans
- Membrane Glycoproteins
- Membrane Proteins
- Methionine Sulfoximine
- Neoplasm Proteins
- Phenotype
- Sulfhydryl Compounds
- Transcription, Genetic