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Article

Mutant p53 expression enhances drug resistance in a hepatocellular carcinoma cell line.

Cancer chemotherapy and pharmacology - 1 Jun 2004

Chan Kin-Tak, Lung Maria Li

Abstract excerpt

Chemoresistance is a major problem in the treatment of hepatocellular carcinoma. Certain p53 mutants may enhance drug resistance in cancer cells. To determine whether two frequently occurring p53 mutants, R248Q and R273C, would increase the drug resistance of liver cancer cells, stable cell lines expressing these specific p53 mutants were established by transfecting the p53-null Hep3B cells with mutant p53...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Apoptosis
Carcinoma, Hepatocellular
Cell Line, Tumor
Cell Survival
DNA, Neoplasm
Doxorubicin
Drug Resistance, Neoplasm
Flow Cytometry
Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

In Situ Nick-End Labeling

Liver Neoplasms

Mutation

Paclitaxel

Transfection

Tumor Suppressor Protein p53

Up-Regulation

Source

Identifiers

PMID: 15004724
DOI: 10.1007/s00280-004-0767-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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