Article
Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations.
Journal of experimental & clinical cancer research : CR - 31 Mar 2016
Jensen Niels Frank, Agama Keli, Roy Amit, Smith David Hersi, Pfister Thomas D, Rømer Maria Unni, Zhang Hong-Liang, Doroshow James H, Knudsen Birgitta R, Stenvang Jan, Brünner Nils, Pommier Yves
Abstract excerpt
BACKGROUND: DNA topoisomerase I (Top1) is a DNA unwinding protein and the specific target of the camptothecin class of chemotherapeutic drugs. One of these, irinotecan, acting through its active metabolite SN-38, is used in the treatment of metastatic colorectal cancer. However, resistance to irinotecan represents a major clinical problem. Since molecular alterations in Top1 may result in resistance to...
Topics
- Benzodioxoles
- Binding Sites
- Camptothecin
- Cell Line, Tumor
- Chromosome Deletion
- Colonic Neoplasms
- DNA Topoisomerases, Type I
- Drug Resistance, Neoplasm
- Epirubicin