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Article

Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations.

Journal of experimental & clinical cancer research : CR - 31 Mar 2016

Jensen Niels Frank, Agama Keli, Roy Amit, Smith David Hersi, Pfister Thomas D, Rømer Maria Unni, Zhang Hong-Liang, Doroshow James H, Knudsen Birgitta R, Stenvang Jan, Brünner Nils, Pommier Yves

Abstract excerpt

BACKGROUND: DNA topoisomerase I (Top1) is a DNA unwinding protein and the specific target of the camptothecin class of chemotherapeutic drugs. One of these, irinotecan, acting through its active metabolite SN-38, is used in the treatment of metastatic colorectal cancer. However, resistance to irinotecan represents a major clinical problem. Since molecular alterations in Top1 may result in resistance to...

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Identifiers

PMID: 27029323
DOI: 10.1186/s13046-016-0335-x
PMCID: PMC4815242

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TOP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations.PMID 27029323Read ↗

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