Mechanisms of resistance in a human cell line exposed to sequential topoisomerase poisoning.

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Article

Mechanisms of resistance in a human cell line exposed to sequential topoisomerase poisoning.

Cancer research - 15 Nov 1997

Saleem A, Ibrahim N, Patel M, Li X G, Gupta E, Mendoza J, Pantazis P, Rubin E H

Abstract excerpt

Camptothecins are a new class of anticancer drugs that target DNA topoisomerase I; current efforts are directed toward elucidating optimal combinations of these drugs with other antineoplastic agents. A rationale for the use of sequential therapy involving the combination of camptothecins with to...

Topics

Antineoplastic Agents
Camptothecin
Cell Nucleus
DNA Topoisomerases, Type I
DNA Topoisomerases, Type II
Drug Resistance, Neoplasm
Etoposide
Humans
Leukemia
Phenotype
Point Mutation
RNA, Messenger
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 9371509

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9371509-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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