Article
Mechanisms of resistance in a human cell line exposed to sequential topoisomerase poisoning.
Cancer research - 15 Nov 1997
Saleem A, Ibrahim N, Patel M, Li X G, Gupta E, Mendoza J, Pantazis P, Rubin E H
Abstract excerpt
Camptothecins are a new class of anticancer drugs that target DNA topoisomerase I; current efforts are directed toward elucidating optimal combinations of these drugs with other antineoplastic agents. A rationale for the use of sequential therapy involving the combination of camptothecins with topoisomerase II-targeting drugs, such as etoposide, has arisen from observations of increased topoisomerase II protein...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.