Article
Rapid development of drug resistance in human ovarian tumor xenografts after a single treatment with melphalan in Vivo.
Anticancer research - 1 Jan 2000
Caffrey P B, Zhang Y, Frenkel G D
Abstract excerpt
Human ovarian tumors from A2780 cells were grown as xenografts in immunodeficient mice, treated with a single i.p. dose of melphalan and tumor cells were removed and placed into tissue culture. The cells from the treated tumors exhibited an approximately 2-fold resistance to melphalan in vitro co...
Topics
- Animals
- Antibiotics, Antineoplastic
- Antimetabolites, Antineoplastic
- Antineoplastic Agents
- Antineoplastic Agents, Alkylating
- Buthionine Sulfoximine
- Cisplatin
- Doxorubicin
- Drug Interactions
- Drug Resistance, Neoplasm
- Female
- Glutathione
- Humans
- Injections, Subcutaneous
- Melphalan
- Mice
- Mice, Nude
- Neoplasm Transplantation