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Article

Effect of tryptophan hydroxylase-2 gene variants on suicide risk in major depression.

Biological psychiatry - 1 Jul 2007

Lopez de Lara Catalina, Brezo Jelena, Rouleau Guy, Lesage Alain, Dumont Mimi, Alda Martin, Benkelfat Chawki, Turecki Gustavo

Abstract excerpt

BACKGROUND: Suicide and depressive disorders are strongly associated, yet not all depressed patients commit suicide. Genetic factors may partly explain this difference. We investigated whether variation at the tryptophan hydroxylase-2 (TPH2) gene and its 5' upstream region may predispose to suicide in major depressive disorder (MDD) and whether this predisposition is mediated by impulsive-aggressive behaviors...

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Source

Identifiers

PMID: 17217922
DOI: 10.1016/j.biopsych.2006.09.008

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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