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Article

Simultaneous analysis of serotonin transporter, tryptophan hydroxylase 1 and 2 gene expression in the ventral prefrontal cortex of suicide victims.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jun 2010

Perroud Nader, Neidhart Elizabeth, Petit Brice, Vessaz Monique, Laforge Térèse, Relecom Céline, La Harpe Romano, Malafosse Alain, Guipponi Michel

Abstract excerpt

Serotonergic signaling abnormalities have been implicated in suicide. Tryptophan hydroxylase (TPH), the rate limiting enzyme of serotonin biosynthesis and the serotonin transporter (SLC6A4), involved in the reuptake of serotonin from the synaptic gap, play major role in serotonergic signaling. In this study, we aimed to compare the levels of expression of these serotonin-related genes between suicide completers...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20052688
DOI: 10.1002/ajmg.b.31059

Genes

TPH2
TPH1

Provenance

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