Article
p53 expression, mutation, and allelic deletion in ovarian cancer.
The Journal of pathology - 1 Nov 1994
McManus D T, Yap E P, Maxwell P, Russell S E, Toner P G, McGee J O
Abstract excerpt
The aim of this investigation was to study the prevalence of p53 gene mutations and allelic deletions in ovarian cancer and the relationship between these events and p53 expression. Genomic p53 was amplified by the polymerase chain reaction (PCR) from paraffin-embedded sections of tumour and non-...
Topics
- Alleles
- Base Sequence
- Chromosome Deletion
- Exons
- Female
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Humans
- Molecular Sequence Data
- Mutation
- Ovarian Neoplasms
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Polymorphism, Single-Stranded Conformational
- Prevalence
- Retrospective Studies
- Tumor Suppressor Protein p53