Article
Regional variations of 5HT concentrations in Rorasg (staggerer) mutants.
Neurochemical research - 1 Jul 2006
Lalonde Robert, Strazielle Catherine
Abstract excerpt
Ataxic Rora(sg) (staggerer) mouse mutants, containing a deletion of the Rora gene which encodes a retinoid-like nuclear receptor, were compared to non-ataxic controls for concentrations of 5-hydroxytryptamine (HT), its main metabolite (5-hydroxy-indole acetic acid, 5HIAA), and its precursor (tryptophan) in cerebellum, brainstem, and forebrain. In Rora(sg) cerebellum, 5HT concentrations increased relative to...
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