Article
Orphan nuclear receptor ROR alpha-deficient mice display the cerebellar defects of staggerer.
Mechanisms of development - 1 Jan 1998
Dussault I, Fawcett D, Matthyssen A, Bader J A, Giguère V
Abstract excerpt
It has recently been shown that the neurological mutant mouse staggerer (sg) harbors a deletion within the Rora gene that encodes the orphan nuclear receptor ROR alpha. This deletion removes an exon encoding part of the ligand binding domain of the putative receptor, generating an ROR alpha trunc...
Topics
- Alleles
- Animals
- Cerebellum
- Female
- Gene Targeting
- Genetic Complementation Test
- Genetic Vectors
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mice, Neurologic Mutants
- Nerve Tissue Proteins
- Nuclear Receptor Subfamily 1, Group F, Member 1
- Phenotype
- Receptors, Cytoplasmic and Nuclear
- Sequence Deletion
- Trans-Activators