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Article

RORalpha, a pivotal nuclear receptor for Purkinje neuron survival and differentiation: from development to ageing.

Cerebellum (London, England) - 1 Jan 2006

Boukhtouche Fatiha, Doulazmi Mohamed, Frederic Florence, Dusart Isabelle, Brugg Bernard, Mariani Jean

Abstract excerpt

RORalpha (Retinoid-related Orphan Receptor) is a transcription factor belonging to the superfamily of nuclear receptors. The spontaneous staggerer (sg) mutation, which consists of a deletion in the Rora gene, has been shown to cause the loss of function of the RORalpha protein. The total loss of RORalpha expression leads to cerebellar developmental defects, particularly to a dramatic decreased survival of...

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Source

Identifiers

PMID: 16818384
DOI: 10.1080/14734220600750184

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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RORalpha, a pivotal nuclear receptor for Purkinje neuron survival and differentiation: from development to ageing.PMID 16818384Read ↗

Age-related phenotypes in the staggerer mouse expand the RORalpha nuclear receptor's role beyond the cerebellum.Semantic proximity Read ↗

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Orphan nuclear receptor ROR alpha-deficient mice display the cerebellar defects of staggerer.Semantic proximity Read ↗

A comparative study of Purkinje cells in two RORalpha gene mutant mice: staggerer and RORalpha(-/-).Semantic proximity Read ↗

staggerer phenotype in retinoid-related orphan receptor alpha-deficient mice.Semantic proximity Read ↗

Global Knockdown of Retinoid-related Orphan Receptor α in Mature Purkinje Cells Reveals Aberrant Cerebellar Phenotypes of Spinocerebellar Ataxia.Semantic proximity Read ↗

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RORA-neurodevelopmental disorder: A unique triad of developmental disabilities, cerebellar anomalies, and myoclonic seizures.Semantic proximity Read ↗

Retinoid-Related Orphan Receptors (RORs): Critical Roles in Development, Immunity, Circadian Rhythm, and Cellular MetabolismSemantic proximity Read ↗

The structural integrity of ROR alpha isoforms is mutated in staggerer mice: cerebellar coexpression of ROR alpha1 and ROR alpha4.Semantic proximity Read ↗

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