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Article

Age-related phenotypes in the staggerer mouse expand the RORalpha nuclear receptor's role beyond the cerebellum.

Molecular and cellular endocrinology - 15 Jan 2002

Jarvis Christopher I, Staels Bart, Brugg Bernard, Lemaigre-Dubreuil Yolande, Tedgui Alain, Mariani Jean

Abstract excerpt

The homozygous mutant mouse staggerer (RORa(sg)/RORa(sg)), was initially described as ataxic, due to the presence of massive neurodegeneration in the cerebellum [Science 136 (1962) 610]. The identification of the widely expressed Retinoic acid receptor-related Orphan Receptor, NR1F1 (RORalpha) gene as the site of mutation in the staggerer mouse has led to great progress in understanding the molecular basis of its...

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PMID: 11850116
DOI: 10.1016/s0303-7207(01)00668-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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