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Article

Abnormal serotonergic development in a mouse model for the Smith-Lemli-Opitz syndrome: implications for autism.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience - 1 Dec 2003

Waage-Baudet H, Lauder J M, Dehart D B, Kluckman K, Hiller S, Tint G S, Sulik K K

Abstract excerpt

The Smith-Lemli-Opitz syndrome (SLOS) is a malformation/mental retardation syndrome resulting from an inborn error in 3beta-hydroxysteroid Delta7-reductase (DHCR7), the terminal enzyme required for cholesterol biosynthesis. Using a targeting strategy designed to virtually eliminate Dhcr7 activity, we have created a SLOS mouse model that exhibits commissural deficiencies, hippocampal abnormalities, and...

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Source

Identifiers

PMID: 14659996
DOI: 10.1016/j.ijdevneu.2003.09.002

Genes

DHCR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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