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Article

staggerer phenotype in retinoid-related orphan receptor alpha-deficient mice.

Proceedings of the National Academy of Sciences of the United States of America - 31 Mar 1998

Steinmayr M, André E, Conquet F, Rondi-Reig L, Delhaye-Bouchaud N, Auclair N, Daniel H, Crépel F, Mariani J, Sotelo C, Becker-André M

Abstract excerpt

Retinoid-related orphan receptor alpha (RORalpha) is a member of the nuclear receptor superfamily. To study its physiological role we generated null-mutant mice by targeted insertion of a lacZ reporter gene encoding the enzyme beta-galactosidase. In heterozygous RORalpha+/- mice we found beta-galactosidase activity, indicative of RORalpha protein expression, confined to the central nervous system, skin and...

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Identifiers

PMID: 9520475
DOI: 10.1073/pnas.95.7.3960
PMCID: PMC19945

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