Article
staggerer phenotype in retinoid-related orphan receptor alpha-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America - 31 Mar 1998
Steinmayr M, André E, Conquet F, Rondi-Reig L, Delhaye-Bouchaud N, Auclair N, Daniel H, Crépel F, Mariani J, Sotelo C, Becker-André M
Abstract excerpt
Retinoid-related orphan receptor alpha (RORalpha) is a member of the nuclear receptor superfamily. To study its physiological role we generated null-mutant mice by targeted insertion of a lacZ reporter gene encoding the enzyme beta-galactosidase. In heterozygous RORalpha+/- mice we found beta-gal...
Topics
- Animals
- Behavior, Animal
- Cerebellum
- Gene Expression Regulation
- Mice
- Mice, Mutant Strains
- Mutation
- Nerve Tissue Proteins
- Nuclear Receptor Subfamily 1, Group F, Member 1
- Organ Specificity
- Receptors, Cytoplasmic and Nuclear
- Trans-Activators