Article
Alteration of cerebellar neurotropin messenger ribonucleic acids and the lack of thyroid hormone receptor augmentation by staggerer-type retinoic acid receptor-related orphan receptor-alpha mutation.
Endocrinology - 1 Apr 2007
Qiu Chun-Hong, Shimokawa Noriaki, Iwasaki Toshiharu, Parhar Ishwar S, Koibuchi Noriyuki
Abstract excerpt
The mutant mouse staggerer (sg) harbors a deletion within the gene encoding the retinoic acid receptor-related orphan receptor-alpha (RORalpha). Homozygotes show aberrant cerebellar development. However, the mechanisms responsible for the cerebellar defect are still poorly understood. In the present study, the involvement of neurotropins (NTs), including nerve growth factor, brain-derived neurotropic factor, NT-3...
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