Article
Dopamine deficiency in a genetic mouse model of Lesch-Nyhan disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Mar 1994
Jinnah H A, Wojcik B E, Hunt M, Narang N, Lee K Y, Goldstein M, Wamsley J K, Langlais P J, Friedmann T
Abstract excerpt
We have examined several aspects of neurotransmitter function in the brains of mice carrying a deletion mutation in the gene encoding the purine salvage enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT). During the first 6 weeks of postnatal development, dopamine levels in whole-brain...
Topics
- 3,4-Dihydroxyphenylacetic Acid
- Aging
- Animals
- Brain
- Caudate Nucleus
- Disease Models, Animal
- Dopamine
- Hydroxyindoleacetic Acid
- Hypoxanthine Phosphoribosyltransferase
- Lesch-Nyhan Syndrome
- Mice
- Mutation
- Norepinephrine
- Phencyclidine
- Putamen