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Article

Dopamine deficiency in a genetic mouse model of Lesch-Nyhan disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Mar 1994

Jinnah H A, Wojcik B E, Hunt M, Narang N, Lee K Y, Goldstein M, Wamsley J K, Langlais P J, Friedmann T

Abstract excerpt

We have examined several aspects of neurotransmitter function in the brains of mice carrying a deletion mutation in the gene encoding the purine salvage enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT). During the first 6 weeks of postnatal development, dopamine levels in whole-brain extracts from the mutant mice (HPRT-) failed to increase at rates comparable to normal animals, resulting in 40% lower...

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Identifiers

PMID: 7509865
PMCID: PMC6577527

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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