Article
Progressive atrophy of cerebellar Purkinje cell dendrites during aging of the heterozygous staggerer mouse (Rora(+/sg)).
Brain research. Developmental brain research - 28 Feb 2001
Hadj-Sahraoui N, Frederic F, Zanjani H, Delhaye-Bouchaud N, Herrup K, Mariani J
Abstract excerpt
Staggerer (Rora(sg/sg)) is an autosomal mutation in an orphan nuclear hormone receptor gene, RORalpha, that acts intrinsically within the Purkinje cells and causes dysgenesis of the cerebellar cortex. Purkinje cell number is severely reduced, and the surviving cells are small with poorly developed dendrites. In contrast, the cytoarchitecture of the cerebellar cortex of the heterozygous staggerer (Rora(+/sg))...
Topics
- Aging
- Animals
- Atrophy
- Cell Death
- Cerebellar Diseases
- Cerebellum
- Dendrites
- Disease Progression
- Genotype
- Heterozygote
- Mice
- Mice, Inbred C57BL