Non-random association between DNA markers and Huntington disease locus in the Italian population.

doi:10.1002/ajmg.1320400326

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Article

Non-random association between DNA markers and Huntington disease locus in the Italian population.

American journal of medical genetics - 1 Sept 1991

Novelletto A, Mandich P, Bellone E, Malaspina P, Vivona G, Ajmar F, Frontali M

Abstract excerpt

A group of Huntington disease (HD) families of Italian ancestry was analyzed for 11 RFLPs from genetic loci mapped in 4p16 and genetically linked to the HD gene. We found a statistically significant difference of allele distributions in HD vs normal chromosomes for loci D4S10, D4S127, and D4S43....

Topics

Alleles
Chromosomes, Human, Pair 4
Gene Frequency
Genetic Markers
Humans
Huntington Disease
Italy
Linkage Disequilibrium
Polymorphism, Restriction Fragment Length

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