Article
Haplotype structure, LD blocks, and uneven recombination within the LRP5 gene.
Genome research - 1 May 2003
Twells Rebecca C J, Mein Charles A, Phillips Michael S, Hess J Fred, Veijola Riitta, Gilbey Matthew, Bright Matthew, Metzker Michael, Lie Benedicte A, Kingsnorth Amanda, Gregory Edward, Nakagawa Yusuke, Snook Hywel, Wang William Y S, Masters Jennifer, Johnson Gillian, Eaves Iain, Howson Joanna M M, Clayton David, Cordell Heather J, Nutland Sarah, Rance Helen, Carr Philippa, Todd John A
Abstract excerpt
Patterns of linkage disequilibrium (LD) in the human genome are beginning to be characterized, with a paucity of haplotype diversity in "LD blocks," interspersed by apparent "hot spots" of recombination. Previously, we cloned and physically characterized the low-density lipoprotein-receptor-related protein 5 (LRP5) gene. Here, we have extensively analysed both LRP5 and its flanking three genes, spanning 269 kb,...
Topics
- 3' Flanking Region
- 5' Flanking Region
- Alleles
- Chromosome Mapping
- Chromosomes, Human, Pair 11
- Diabetes Mellitus, Type 1
- Gene Frequency
- Genetic Markers