Linkage of Wolfram syndrome to chromosome 4p16.1 and evidence for heterogeneity.

Article

Linkage of Wolfram syndrome to chromosome 4p16.1 and evidence for heterogeneity.

American journal of human genetics - 1 Oct 1996

Collier D A, Barrett T G, Curtis D, Macleod A, Arranz M J, Maassen J A, Bundey S

Abstract excerpt

Wolfram syndrome (DIDMOAD syndrome; MIM 222300) is an autosomal recessive neurodegenerative disorder characterized by juvenile-onset diabetes mellitus and bilateral optic atrophy. Previous linkage analysis of multiply affected families indicated that the gene for Wolfram syndrome is on chromosome...

Topics

Adolescent
Adult
Chromosomes, Human, Pair 4
Female
Genetic Heterogeneity
Genetic Linkage
Genotype
Haploidy
Humans
Male
Middle Aged
Pedigree
Wolfram Syndrome

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