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Oxidative DNA damage and reporter gene mutation in the livers of gpt delta rats given non-genotoxic hepatocarcinogens with cytochrome P450-inducible potency.

Cancer science - 1 Dec 2010

Tasaki Masako, Umemura Takashi, Suzuki Yuta, Hibi Daisuke, Inoue Tomoki, Okamura Toshiya, Ishii Yuji, Maruyama Soichi, Nohmi Takehiko, Nishikawa Akiyoshi

Abstract excerpt

Previous reports have proposed that reactive oxygen species resulting from induction of cytochrome P450 (CYP) isozymes might be involved in the modes of action of hepatocarcinogens with CYP-inducible potency. In the present study, we investigated 8-hydroxydeoxyguanosine (8-OHdG) levels, in vivo mutagenicity and glutathione S-transferase placental form (GST-P)-positive foci in the livers of gpt delta rats treated...

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Identifiers

PMID: 20735435
DOI: 10.1111/j.1349-7006.2010.01705.x
PMCID: PMC11159437

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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