Article
DNA adduct level induced by 2-amino-3,4-dimethylimidazo[4,5-f]-quinoline in Big Blue mice does not correlate with mutagenicity.
Mutagenesis - 1 Jul 1998
Ochiai M, Ishida K, Ushijima T, Suzuki T, Sofuni T, Sugimura T, Nagao M
Abstract excerpt
In previous experiments we analyzed the mutant frequency (MF) and mutational types in various organs of lacI transgenic mice which were fed a diet containing 300 p.p.m. 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ), a food-borne mutagen/carcinogen. To clarify the relationships between mutati...
Topics
- Animals
- Bacterial Proteins
- DNA Adducts
- Escherichia coli Proteins
- Female
- Lac Repressors
- Mice
- Mice, Inbred Strains
- Mice, Transgenic
- Mutagenicity Tests
- Mutagens
- Mutation
- Quinolines
- Repressor Proteins
- Time Factors
- Tissue Distribution