Article
Influence of polymorphisms of ABCB1 and ABCC2 on mRNA and protein expression in normal and cancerous kidney cortex.
The pharmacogenomics journal - 1 Feb 2007
Haenisch S, Zimmermann U, Dazert E, Wruck C J, Dazert P, Siegmund W, Siegmund S, Kroemer H K, Warzok R W, Cascorbi I
Abstract excerpt
There is increasing evidence that polymorphisms of the adenosine 5' triphosphate membrane transporters ABCB1 (P-glycoprotein, MDR1) may affect expression and function, whereas less information is available about the impact of ABCC2 (multidrug resistance-associated protein (MRP2)) single-nucleotide polymorphisms . Particularly, their role in human kidney for drug elimination and in the etiology of renal cell...
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