Cytochrome P450 1B1 polymorphisms and risk of renal cell carcinoma in men.

doi:10.1007/s13277-014-2292-3

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Article

Cytochrome P450 1B1 polymorphisms and risk of renal cell carcinoma in men.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Oct 2014

Chang Inik, Fukuhara Shinichiro, Wong Darryn K, Gill Ankurpreet, Mitsui Yozo, Majid Shahana, Saini Sharanjot, Yamamura Soichiro, Chiyomaru Takeshi, Hirata Hiroshi, Ueno Koji, Arora Sumit, Shahryari Varahram, Deng Guoren, Tabatabai Z Laura, Greene Kirsten L, Shin Dong Min, Enokida Hideki, Shiina Hiroaki, Nonomura Norio, Dahiya Rajvir, Tanaka Yuichiro

Abstract excerpt

The cytochrome P450 1B1 (CYP1B1) enzyme activates xenobiotics to reactive forms as well as convert estradiol to 4-hydroxy-estradiol that has been shown to play a role in the carcinogenesis process of the kidney in male but not female animals. Prior reports show polymorphic variants of CYP1B1 to alter catalytic activity, and thus, we hypothesize that polymorphisms of the CYP1B1 gene are involved in the malignant...

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PMID: 25027399
DOI: 10.1007/s13277-014-2292-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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