Article
Functional properties of an alternative, tissue-specific promoter for human arylamine N-acetyltransferase 1.
Pharmacogenetics and genomics - 1 Jul 2006
Barker David F, Husain Anwar, Neale Jason R, Martini Benjamin D, Zhang Xiaoyan, Doll Mark A, States J Christopher, Hein David W
Abstract excerpt
Variable expression of human arylamine N-acetyltransferase 1 (NAT1) due to genetic polymorphism, gene regulation or environmental influences is associated with individual susceptibility to various cancers. Recent studies of NAT1 transcription showed that most mRNAs originate at a promoter, P1, located 11.8 kb upstream of the single open reading frame (ORF) exon. We have now characterized an alternative NAT1...
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