Phenotype of the most common "slow acetylator" arylamine N-acetyltransferase 1 genetic variant (NAT1*14B) is substrate-dependent.

doi:10.1124/dmd.111.041855

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Article

Phenotype of the most common "slow acetylator" arylamine N-acetyltransferase 1 genetic variant (NAT1*14B) is substrate-dependent.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2012

Millner Lori M, Doll Mark A, Cai Jian, States J Christopher, Hein David W

Abstract excerpt

Human arylamine N-acetyltransferase 1 (NAT1) is a phase II cytosolic enzyme responsible for the activation or deactivation of many arylamine compounds including pharmaceuticals and environmental carcinogens. NAT1 is highly polymorphic and has been associated with altered risk toward many cancers. NAT1*14B is characterized by a single nucleotide polymorphism in the coding region (rs4986782; 560G>A; R187Q)....

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PMID: 22010219
DOI: 10.1124/dmd.111.041855
PMCID: PMC3250052

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NAT1

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