Article
Functional analysis of arylamine N-acetyltransferase 1 (NAT1) NAT1*10 haplotypes in a complete NATb mRNA construct.
Carcinogenesis - 1 Feb 2012
Millner Lori M, Doll Mark A, Stepp Marcus W, States J Christopher, Hein David W
Abstract excerpt
N-acetyltransferase 1 (NAT1) catalyzes N-acetylation of arylamines as well as the O-acetylation of N-hydroxylated arylamines. O-acetylation leads to the formation of electrophilic intermediates that result in DNA adducts and mutations. NAT1*10 is the most common variant haplotype and is associated with increased risk for numerous cancers. NAT1 is transcribed from a major promoter, NATb, and an alternative...
Topics
- 3' Untranslated Regions
- 5' Untranslated Regions
- Acetylation
- Aminobiphenyl Compounds
- Animals
- Arylamine N-Acetyltransferase
- CHO Cells
- Cell Line, Tumor
- Cells, Cultured
- Cricetinae
- DNA Adducts
- DNA Repair
- Haplotypes
- Hep G2 Cells