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Article

Functional analysis of the human N-acetyltransferase 1 major promoter: quantitation of tissue expression and identification of critical sequence elements.

Drug metabolism and disposition: the biological fate of chemicals - 1 Sept 2007

Husain Anwar, Zhang Xiaoyan, Doll Mark A, States J Christopher, Barker David F, Hein David W

Abstract excerpt

Arylamine N-acetyltransferase 1 (NAT1) plays an important role in the biotransformation of xenobiotics, and genetic variants have been implicated in susceptibility to cancer and birth defects. A specific and quantitative reverse transcription-polymerase chain reaction assay for transcription from the major NAT1 promoter detected high expression with limited variability in human tissues. A 213-base pair (bp)...

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Source

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Identifiers

PMID: 17591675
DOI: 10.1124/dmd.107.016485
PMCID: PMC2085369

Genes

NAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional analysis of the human N-acetyltransferase 1 major promoter: quantitation of tissue expression and identification of critical sequence elements.PMID 17591675Read ↗

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