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Article

Human N-acetyltransferase 1 10 and 11 alleles increase protein expression through distinct mechanisms and associate with sulfamethoxazole-induced hypersensitivity.

Pharmacogenetics and genomics - 1 Oct 2011

Wang Danxin, Para Michael F, Koletar Susan L, Sadee Wolfgang

Abstract excerpt

OBJECTIVES: N-acetyltransferase 1 (NAT1) metabolizes drugs and environmental carcinogens. NAT1 alleles *10 and *11 have been proposed to alter protein level or enzyme activity compared with wild-type NAT1 *4 and to confer cancer risk, through uncertain pathways. This study characterizes regulatory polymorphisms and underlying mechanisms of NAT1 expression. METHODS: We measured allelic NAT1 mRNA expression and...

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Identifiers

PMID: 21878835
DOI: 10.1097/FPC.0b013e3283498ee9
PMCID: PMC3172334

Genes

NAT1
NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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