Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of arylamine N-acetyltransferases.

Current drug metabolism - 1 Jul 2008

Butcher Neville J, Tiang Jacky, Minchin Rodney F

Abstract excerpt

Acetylation catalysed by the arylamine N-acetyltransferases (NATs; 2.3.1.5) is a major biotransformation pathway for arylamine and hydrazine drugs, as well as many carcinogens that we are exposed to on a daily basis. These compounds can either be detoxified by NATs or bioactivated to metabolites that have the potential to cause toxicity such as cancer. As a result, the levels of NATs in the body have clinical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Xenobiotics
Share to Transcription, Genetic
Share to Arylamine N-Acetyltransferase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enzyme Inhibitors

Share to Gene Expression Regulation, Enzymologic

Share to Neoplasms

Share to Promoter Regions, Genetic

Share to Protein Processing, Post-Translational

Source

Identifiers

PMID: 18680469
DOI: 10.2174/138920008784892128

Genes

NAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of arylamine N-acetyltransferases.PMID 18680469Read ↗

Pharmacogenetics, Regulation and Structural Properties of the Drugmetabolizing Enzymes Arylamine N-acetyltransferases.Semantic proximity Read ↗

Regulation of the activity of the human drug metabolizing enzyme arylamine N-acetyltransferase 1: role of genetic and non genetic factors.Semantic proximity Read ↗

Pharmacogenetics of the arylamine N-acetyltransferases.Semantic proximity Read ↗

ArylamineN-acetyltransferasesSemantic proximity Read ↗

Polymorphism of human acetyltransferases.Semantic proximity Read ↗

Pharmacogenomics of Arylamine N-acetyltransferase.Semantic proximity Read ↗

Arylamine N-acetyltransferases: From Structure to FunctionSemantic proximity Read ↗

Polymorphisms of human N-acetyltransferases and cancer risk.Semantic proximity Read ↗

Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N-Acetyltransferase NAT2.Semantic proximity Read ↗

Generation and functional characterization of arylamine N-acetyltransferase Nat1/Nat2 double-knockout mice.Semantic proximity Read ↗

Arylamine N-acetyltransferase.Semantic proximity Read ↗

[The biological role of prokaryotic and eukaryotic N-acetyltransferase].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.