Article
Genetic variations and haplotypes of CYP2C19 in a Japanese population.
Drug metabolism and pharmacokinetics - 1 Aug 2005
Fukushima-Uesaka Hiromi, Saito Yoshiro, Maekawa Keiko, Ozawa Shogo, Hasegawa Ryuichi, Kajio Hiroshi, Kuzuya Nobuaki, Yasuda Kazuki, Kawamoto Manabu, Kamatani Naoyuki, Suzuki Kazuko, Yanagawa Tatsuo, Tohkin Masahiro, Sawada Jun-Ichi
Abstract excerpt
Forty-eight single nucleotide variations, including 27 novel ones, were found in the 5'- regulatory region, all of the exons and their surrounding introns of CYP2C19 in 253 Japanese subjects (134 diabetic patients and 119 healthy volunteers). Identified novel variations were as follows: -2772G>A, 2767_-2760delGGTGAACA, -2720T>C, -2547delG, -2545G>T, -2545_-2544 delGC, and -2040C>T in the enhancer region; -778C>T,...
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