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Article

Exclusive HLA-DQ factors do not explain susceptibility to insulin-dependent diabetes.

Human immunology - 1 Jun 1991

Martinez-Laso J, Vicario J L, Corell A, Martin-Villa J M, Morales P, Lledó G, Arnaiz-Villena A

Abstract excerpt

DQA1, DQA2, DQB1, and DRB1 alleles have been determined and the DQA1 and DQB1 DNA gene sequences assigned by using restriction fragment length polymorphisms in 67 diabetic individuals and 72 controls. It has been found that: 1) DQA2 (U allele) is not a susceptibility factor, 2) non-aspartic acid homozygosity in residue 57 (Asp 57 negative) of the DQ beta chains is positively correlated with insulin-dependent...

Topics

Alleles
Arginine
Aspartic Acid
DNA Probes
Diabetes Mellitus, Type 1
HLA-DQ Antigens
HLA-DR Antigens
Histocompatibility Testing
Humans
Polymorphism, Restriction Fragment Length
Risk Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1676704
DOI: 10.1016/0198-8859(91)90016-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1676704-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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