Susceptibility to type 1 (insulin-dependent) diabetes mellitus in Spanish patients correlates quantitatively with expression of HLA-DQ alpha Arg 52 and HLA-DQ beta non-Asp 57 alleles.

doi:10.1007/BF00400488

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Article

Susceptibility to type 1 (insulin-dependent) diabetes mellitus in Spanish patients correlates quantitatively with expression of HLA-DQ alpha Arg 52 and HLA-DQ beta non-Asp 57 alleles.

Diabetologia - 1 Jun 1992

Gutierrez-Lopez M D, Bertera S, Chantres M T, Vavassori C, Dorman J S, Trucco M, Serrano-Rios M

Abstract excerpt

HLA-DQ alpha and beta alleles were chosen as the most sensitive Type 1 (insulin-dependent) diabetes mellitus susceptibility markers for evaluating the disease associations and Type 1 diabetes risk in a population-based registry from Madrid. The absence of aspartic acid in position 57 of the DQ be...

Topics

Alleles
Arginine
Aspartic Acid
Base Sequence
Cells, Cultured
Diabetes Mellitus, Type 1
Disease Susceptibility
Gene Frequency
Genetic Predisposition to Disease
Genotype
HLA-DQ Antigens
HLA-DQ alpha-Chains
HLA-DQ beta-Chains
Homozygote

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Lymphocytes

Molecular Sequence Data

Oligodeoxyribonucleotides

Source

Open in PubMed

Identifiers

PMID: 1612233
DOI: 10.1007/BF00400488

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1612233-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.