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Article

Natural polymorphisms in the protease gene modulate the replicative capacity of non-B HIV-1 variants in the absence of drug pressure.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Aug 2006

Holguín Africa, Suñe Carlos, Hamy François, Soriano Vincent, Klimkait Thomas

Abstract excerpt

BACKGROUND: Genetic variation in the HIV-1 pol gene, which encodes the main targets for anti-HIV drugs, may favors different susceptibility and resistance pathways to antiretroviral agents. Several amino acid substitutions occur frequently in some non-B viruses at positions associated with drug resistance in clade B viruses. The clinical relevance of those polymorphisms is unclear. OBJECTIVE: To evaluate the...

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Identifiers

PMID: 16765636
DOI: 10.1016/j.jcv.2006.05.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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